Kolorektal adenoma ve karsinomlu hastalarda metabolik ve inflamatuvar risk faktörlerinin değerlendirilmesi

Background and Aims: Metabolic syndrome its related components are thought to be risk factors for developing colorectal neoplasms due hyperinsulinemia, insulin resistance, oxidative stress resulting in chronic low-grade inflammation. This study aims explain the association of (colon adenocarcinoma colon adenoma) with metabolic components, non-alcoholic fatty liver disease, inflammatory markers. Materials Methods: Data 151 patients diagnosed adenoma were retrospectively reviewed. Demographic characteristics, routine blood tests, colonoscopic findings, pathology results, tumor-node-metastasis stages adenocancer, hepatic ultrasonography findings recorded. The Homeostatic Model Assessment Insulin Resistance scores calculated. Results: cohort consisted 71 80 adenocancer. number diabetes mellitus, hypertension, hypertriglyceridemia, syndrome, severe steatosis was significantly higher adenocancer group compared group. Additionally, neutrophil-lymphocyte ratio, C-reactive protein, protein albumin ratio In univariant analysis, found have a shorter duration survival than those who did not these factors. multivariate advanced stage, hepatosteatosis, hypertriglyceridemia independent Conclusions: steatosis, process may transition from cancer patients.